Perinatal hypoxia may induce some neural disease of infants. Damage model of fetus rat brain was made by incubation in oxygen and glucose deprived artificial cerebrosinal for the investigation of the protective effect of oxytocin. Electron micrograph showed that oxytocin could decrease the apoptosis. Results of immunohistochemistry experiments showed that oxytocin could increase oxytocin receptor (OTR) and gamma-aminobutyric acid receptor A β1 subunit (GABAARβ1).It was concluded that oxytocin possessed protective effect on neurone damage of fetus rats.
于 红,陆廷凤,沈 杨,任慕兰,王少华.缩宫素对胎鼠脑缺氧损伤的保护作用[J]. Journal of China Pharmaceutical University,2010,41(6):568-571Copy