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附子的新二萜生物碱
投稿时间:2017-05-09  修订日期:2017-06-07  点此下载全文
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作者单位E-mail
房大庆 中国药科大学 wanghao@cpu.edu.cn 
汪豪 中国药科大学 wanghao@cpu.edu.cn 
基金项目:雷公藤属木栓烷类化合物Lck激酶 抑制构效关系与作用机制研究(81573309)
中文摘要:采用Al2O3、硅胶柱色谱、及制备高效液相色谱等方法对附子Aconitum carmichaeli的化学成分进行分离纯化,通过NMR,MS,和单晶X衍射等波谱技术鉴定化合物结构,分离鉴定了4个化合物,分别为:(13R, 15S, 19S)-13, 15, 19-三羟基-海替生(1),附子灵(2),尼奥灵(3),和北乌亭(4)。化合物1为新化合物。
中文关键词:附子  二萜生物碱  结构鉴定
 
One New Diterpenoid alkaloid from Aconitum carmichaeli
Abstract:Four compounds were isolated from the lateral roots of Aconitum carmichaeli by Al2O3, silica gel and preparative HPLC column chromatography. Their structures were identified as: (13R, 15S, 19S)-13, 15, 19-triol-hetisan (1), fuziline (2), neoline (3) and beiwutine (4),by methods of NMR, MS spectroscopic analyses, as well as single crystal X-ray crystallography. Among them, compound 1 was a new diterpenoid alkaloid.
keywords:Aconitum carmichaeli  diterpenoid alkaloids  structure identification
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