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硫化氢供体分子研究进展
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引用本文:申欣欣,张奕华,黄张建.硫化氢供体分子研究进展[J].中国药科大学学报,2019,50(3):265-272.
Cite:SHEN Xinxin,ZHANG Yihua,HUANG Zhangjian.Research advances in hydrogen sulfide donors[J].J China Pharm Univ,2019,50(3):265-272.
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作者单位
申欣欣 中国药科大学新药研究中心 
张奕华 中国药科大学新药研究中心 
黄张建 中国药科大学新药研究中心 
基金项目:国家自然科学基金资助项目(No.81822041,No.81773573,No.81673305)
中文摘要:硫化氢(H2S)是一种内源性的气体信使分子,具有极其广泛的生物学活性,包括舒张血管、保护心脏、抗炎、抗氧化、抗肿瘤等。和其他气体信使分子一样,H2S的活性和其释放的部位、浓度以及持续时间密切相关。因此,H2S供体药物研究的关键科学问题在于如何提高H2S供体分子的选择性,在靶部位(一般为病变部位)释放适当浓度的H2S,发挥治疗作用的同时限制其不良反应。本文综述了两大类H2S供体分子的结构及其释放H2S的机制,重点介绍近年来发展的具有可控释放潜力的H2S供体药物,旨在为H2S供体药物研究提供新的思路。
中文关键词:H2S供体  选择性  硫醇  碳酸酐酶  羰基硫化物
 
Research advances in hydrogen sulfide donors
Abstract:Hydrogen sulfide(H2S)is an endogenous gas messenger molecule with extremely broad biological activities including vasodilation, anti-oxidation, anti-inflammation, cardioprotection and anti-tumor. Similar to other gas messenger molecules, the biological activity of H2S is dependent on its location, concentration and duration of exposure. Therefore, the key scientific issue is how to improve the selectivity of H2S donor molecules to release appropriate concentrations of H2S at the target site(commonly pathological place), exerting therapeutic efficacy with limited side-effects. This article reviews the structures and H2S release mechanisms of two classes of H2S donors focusing on the advances in the recently developed H2S donors with controllable release potential of H2S, thus providing new ideas for future H2S-based drug research.
keywords:H2S donors  selectivity  thiol  carbonic anhydrase  carbonyl sulfide
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