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富勒烯及其衍生物在医药领域的应用研究进展
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引用本文:刘泽员,郭亮亮,张静.富勒烯及其衍生物在医药领域的应用研究进展[J].中国药科大学学报,2018,49(2):136-146.
Cite:LIU Zeyuan,GUO Liangliang,ZHANG Jing.Application progress of fullerene and its derivatives in medicine[J].J China Pharm Univ,2018,49(2):136-146.
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作者单位
刘泽员 郑州大学化工与能源学院 
郭亮亮 郑州大学化工与能源学院 
张静 郑州大学化工与能源学院 
基金项目:国家自然科学基金资助项目(No.81101748);河南省重点科技攻关基金资助项目(No.112300410316)
中文摘要:富勒烯是一种有效的自由基清除剂和抗氧化剂,对富勒烯进行化学修饰得到的富勒烯衍生物具有良好的水溶性及生物活性。富勒烯及其衍生物具有抗氧化、细胞保护、抗微生物、光动力、载带药物和肿瘤治疗等多种活性,在医药领域发挥着重要作用,近几年这方面的研究又取得了较大进展。本文从调控肿瘤微环境、应用于药物载体和光动力疗法、抗氧化应激4个方面综述了富勒烯及其衍生物在医药领域的最新应用研究进展,并对其在医药领域的未来发展及应用进行展望。
中文关键词:富勒烯  衍生物  医药  应用
 
Application progress of fullerene and its derivatives in medicine
Abstract:Fullerene is an effective free radical scavenger and antioxidant. The fullerene derivatives obtained by chemical modification of fullerene have good water solubility and biological activities. Fullerene and its derivatives have many advantages in cell protection and antioxidant properties, antibacterial activity, antiviral activity, photodynamic activity, drug delivery and anti-tumor activities, playing an important role in the field of medicine. In recent years, great progress has been made in this field. In this review, we summarized the latest research progress and applications of fullerene and its derivatives in medicine field at home and abroad from four aspects of regulating tumor microenvironment, drug delivery, photodynamic therapy and anti-oxidative stress. At last, the future development and application of fullerene and its derivatives in the domain of medicine are prospected.
keywords:fullerene  derivatives  medicine  applications
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