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Ras/Raf/MEK/ERK信号通路参与自噬调控作用的研究进展
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引用本文:王雪,张评浒.Ras/Raf/MEK/ERK信号通路参与自噬调控作用的研究进展[J].中国药科大学学报,2017,48(1):110-116.
Cite:WANG Xue,ZHANG Pinghu.Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway[J].J China Pharm Univ,2017,48(1):110-116.
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作者单位
王雪 中国药科大学江苏省新药筛选重点实验室 
张评浒 中国药科大学江苏省新药筛选重点实验室 
基金项目:新世纪优秀人才计划资助项目(No.NCET-12-0975);教育部回国留学人才启动项目资助项目;江苏省新药筛选重点实验室自主探索项目资助项目(No.JKLDS2015ZZ-8)
中文摘要:自噬是机体保守的自我防御机制,是将细胞内变形坏死的细胞器和多余蛋白降解为小分子,以供循环利用。自噬在生理和病理状态下均发挥重要作用,可通过多条信号通路影响胞内物质的表达。目前已知Ras/Raf/MEK/ERK信号通路不仅广泛参与调控细胞生长、增殖、分化、凋亡等多个生理病理过程,并且参与调控自噬,并具有促进肿瘤细胞发生自噬性死亡的作用,但是其具体参与调控自噬的作用机制尚未完全阐明。本文就Ras/Raf/MEK/ERK信号通路参与调控自噬的作用的研究进展进行详细阐述,以期为研究Ras/Raf/MEK/ERK信号通路调控自噬的作用机制提供参考。
中文关键词:Ras/Raf/MEK/ERK信号通路  自噬  B-Raf  K-Ras  抗肿瘤
 
Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway
Abstract:Autophagy is a conserved self-defense mechanism of organism, degrading the necrotic organelles and excess protein into small molecules for recycling. Autophagy plays a role in both physiological and pathological condition, influencing the expression of intracellular substance through multiple signaling pathways. Although it has been demonstrated that Ras/Raf/MEK/ERK signaling pathway was not only extensively involved in the regulation of cell growth, proliferation, differentiation and apoptosis, but was also implicated in autophagy and autophagic cell death, though its detailed mechanisms involved in regulation of autophagy has not been fully elucidated yet. This review focused on the advances of autophagy induced by Ras/Raf/MEK/ERK signaling pathway, to better understand the role of Ras/Raf/MEK/ERK signaling pathway in regulation of autophagy.
keywords:Ras/Raf/MEK/ERK pathway  autophagy  B-Raf  K-Ras  anti-tumor
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