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大花紫玉盘的化学成分
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引用本文:朱倩,黄启龙,张春磊,曹征宇.大花紫玉盘的化学成分[J].中国药科大学学报,2019,50(6):666-671.
Cite:ZHU Qian,HUANG Qilong,ZHANG Chunlei,CAO Zhengyu.Chemical constituents of Uvaria grandiflora[J].J China Pharm Univ,2019,50(6):666-671.
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作者单位
朱倩 中国药科大学江苏省中药评价与转化重点实验室 
黄启龙 中国药科大学江苏省中药评价与转化重点实验室 
张春磊 中国药科大学江苏省中药评价与转化重点实验室 
曹征宇 中国药科大学江苏省中药评价与转化重点实验室 
基金项目:国家自然科学基金资助项目(No.81872974,No.81603389);江苏省自然科学基金资助项目(No.BK20160754)
中文摘要:通过正相硅胶、反相硅胶、大孔吸附树脂、Sephadex LH-20和高效液相色谱等多种现代色谱技术对番荔枝科紫玉盘属植物大花紫玉盘(Uvaria grandiflora)干燥根的化学成分进行系统地分离纯化,得到12个化合物,用现代波谱技术确定化合物的结构分别为:epicatechin-(4β→1′,2→O→2′)-phloroglucinol(1),proanthocyanidin A-1(2),proanthocyanidin A-2(3),表儿茶素(epicatechin)(4),phlorizin(5),圣草酚(eriodictyol)(6),erythro-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(7),threo-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(8),erythro-guaiacylglycerol-8-O-4′-(sinapyl alcohol)ether(9),threo-syringylglycerol-8-O-4′-(sinapyl alcohol)ether(10),burselignan(11),icariol A2(12)。化合物1~12均为首次从该植物中分离得到,其中化合物1为新天然化合物。
中文关键词:大花紫玉盘  化学成分  黄烷醇  木脂素  分离  鉴定
 
Chemical constituents of Uvaria grandiflora
Abstract:Chemical investigation of the roots of Uvaria grandiflora by repeated column chromatography(CC)over silica gel, ODS, Sephadex LH-20, and HPLC resulted in the isolation of twelve compounds. Their structures were identified as: epicatechin-(4β→1′, 2→O→2′)-phloroglucinol(1), proanthocyanidin A-1(2), proanthocyanidin A-2(3), epicatechin(4), phlorizin(5), eriodictyol(6), erythro-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(7), threo-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(8), erythro-guaiacylglycerol-8-O-4′-(sinapyl alcohol)ether(9), threo-syringylglycerol-8-O-4′-(sinapyl alcohol)ether(10), burselignan(11)and icariol A2(12). Compounds 1 to 12 were all isolated from this plant for the first time, and compound 1 was a new natural product.
keywords:Uvaria grandiflora  chemical constituents  lignanoids  flavanols  isolation  identification
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