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药源性胃肠道出血及其病理机制的研究进展
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引用本文:徐晗,张媛媛,寇俊萍.药源性胃肠道出血及其病理机制的研究进展[J].中国药科大学学报,2019,50(6):659-665.
Cite:XU Han,ZHANG Yuanyuan,KOU Junping.Advances in drug-induced gastrointestinal bleeding and its pathological mechanism[J].J China Pharm Univ,2019,50(6):659-665.
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作者单位
徐晗 中国药科大学中药学院中药药理与中医药系江苏省中药评价与转化重点实验室 
张媛媛 中国药科大学中药学院中药药理与中医药系江苏省中药评价与转化重点实验室 
寇俊萍 中国药科大学中药学院中药药理与中医药系江苏省中药评价与转化重点实验室 
中文摘要:药源性胃肠道出血是由于药物作用于胃肠道,引发胃肠黏膜糜烂、出血。引发胃肠道出血的常见药物包括非甾体抗炎药、抗血栓药、化疗药、抗菌药等,药物通过破坏胃肠道黏膜屏障、抑制血管生成、破坏机体凝血机制等途径诱发胃肠道出血,临床尚缺乏有效的防治办法。本文从药物临床研究现状和病理机制出发,综述了近5年国内外对药物引发胃肠道出血的研究进展,以期阐释药物引发胃肠道出血的作用特点,为发现防治药源性胃肠道出血的可能策略提供参考和线索。
中文关键词:胃肠道出血  机制  信号途径  进展
 
Advances in drug-induced gastrointestinal bleeding and its pathological mechanism
Abstract:Drug-induced gastrointestinal bleeding is caused by drugs acting on the gastrointestinal tract, which damages the gastrointestinal mucosa causing erosion and ulceration. Many drugs can cause gastrointestinal bleeding including non-steroidal anti-inflammatory drugs, antithrombotic drugs, chemotherapy drugs, and antibacterial drugs, drugs induced gastrointestinal bleeding by destroying gastrointestinal mucosal barrier, inhibiting of angiogenesis, destroying coagulation mechanism and there are still few prevention methods. This study focused on the clinical research and mechanism of drugs. The research in recent 5 years were reviewed to illustrate drug-induced gastrointestinal bleeding, so as to illustrate the characteristic actions of drug and provide some references and clues for the prevention of drug-induced gastrointestinal bleeding.
keywords:gastrointestinal bleeding  mechanism  signaling pathway  advances
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