站内搜索
最新录用更多>>
药物的共晶与盐
    点此下载全文
引用本文:马坤,高静,马磊.药物的共晶与盐[J].中国药科大学学报,2012,43(5):475-480.
Cite:MA Kun,GAO Jing,MA Lei.Pharmaceutical cocrystals and salts[J].J China Pharm Univ,2012,43(5):475-480.
摘要点击次数: 3252
全文下载次数: 5937
作者单位
马坤 国家食品药品监督管理局药品审评中心 
高静 中国药科大学中药制剂教研室 
马磊 国家食品药品监督管理局药品审评中心 
中文摘要:药物的固体形态直接影响其安全性与有效性,共晶和盐作为两种不同的固体形态,可有效改善药物的理化性质,是目前制药工业领域的研究热点。本文归纳并总结了共晶和盐的研究现状,结合FDA最新发布的《药物共晶监管分类指南》,根据各自的物理结构差异,阐明了共晶和盐的不同定义,讨论了两者在提高药物溶解度、稳定性和生物利用度等方面的作用和可能存在的问题,介绍了一些重要的鉴别共晶与盐的现代分析方法。
中文关键词:共晶    质子转移  客分子
 
Pharmaceutical cocrystals and salts
Abstract:New solid forms with modified physicochemical and biopharmaceutical properties can be obtained by introducing different guest molecules to form cocrystals or salts.This approach appears to be an advantageous alternative for pharmaceutical research and development.Inspired by the newly released Guidance for Industry:Regulatory Classification of Pharmaceutical Cocrystals,we reviewed the differences between cocrystals and salts in their definition,structure,characterization,regulatory issues and physicochemical properties such as solubility,stability as well as bioavailability.In addition,some newly developed techniques for characterizing cocrystals or salts are also introduced.
keywords:cocrystal  salt  proton transfer  guest molecule
查看全文  查看/发表评论  下载PDF阅读器
分享按钮