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前列腺素受体及相关药物的研究进展
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引用本文:徐 红,孙宏斌.前列腺素受体及相关药物的研究进展[J].中国药科大学学报(中文版),2010,41(5):385-394
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作者单位
徐 红 中国药科大学新药研究中心 
孙宏斌 中国药科大学新药研究中心 
中文摘要:前列腺素是一类具有广泛生理活性的内源性化合物,目前发现的天然前列腺素有20多种,而合成的前列腺素类化合物大约有2 000种,临床上可用作消化系统、心血管系统、生殖系统疾病用药及治疗青光眼。该类化合物体内的受体类型多,可以偶联G蛋白介导多种生理病理过程,例如哮喘、疼痛和炎症等。本文主要以前列腺素受体为分类依据,综述各类受体的特性以及相关药物的临床应用和研究进展。
中文关键词:前列腺素  G蛋白偶联受体  信号通路
 
Research progress of prostaglandin receptors and related drugs
Abstract:Prostaglandins is a kind of endogenous compounds with extensive physiological activities,and more than twenty kinds of natural prostaglandins have been found,while about two thousand prostanoid have been synthetized.These compounds have been developed as therapic agents,which are used in alimentary system,cardiovascular system, genital system and anti-glaucoma.Numerous types of prostaglandin receptors exist in organism,belonging to G-protein-coupled receptor superfamily,mediate multiple physiological and pathological processes,such as asthma,pain and inflammation.This review summarizes the properties of each type of prostaglandin receptor,and the clinical applications and research progress of drugs targeting their corresponding prostaglandin receptors.
keywords:prostaglandin  G-protein-coupled receptor  signaling pathway
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